Turk J Med Sci. 2020 Aug 11. Epub 2020 Aug 11. PMID: 32777902
Melatonin, Aging and COVID-19: Could melatonin be beneficial for COVID-19 treatment in elderly?
The aim of this review is to summarize current studies on the relationship between melatonin and aging. Nowadays, age-related diseases come into prominence, and identifying age-related changes and developing proper therapeutic approaches are counted in major issues of community health. Melatonin is the main hormone of the pineal gland. Melatonin is known to influence many biological processes in the body, including circadian rhythms, immune system, neuroendocrine and cardiovascular functions. Melatonin rhythms also reflect the biological process of aging. Aging is an extremely complex and multifactorial process. Melatonin levels decline considerably with aging and its loss is associated with several age-related diseases. Aging is closely associated with oxidative damage and mitochondrial dysfunction. Free radical reactions initiated by the mitochondria constitute the inherent aging process. Melatonin plays a pivotal role to prevent the age-related oxidative stress. COVID-19 fatality rates increase with chronic diseases and age, where melatonin levels are also decrease. For this reason, melatonin supplementation in elderly could be beneficial in COVID-19 treatment. Therefore, studies on usage of melatonin in COVID-19 treatment are needed.